| 000 -LEADER |
|---|
| fixed length control field |
02435cam a22003134a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER |
|---|
| control field |
OSt |
| 005 - DATE AND TIME OF LATEST TRANSACTION |
|---|
| control field |
20190415143103.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
|---|
| fixed length control field |
100427s2010 flua b 001 0 eng |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER |
|---|
| International Standard Book Number |
9781420073492 (hardcover : alk. paper) |
|
|---|
| International Standard Book Number |
1420073494 (hardcover : alk. paper) |
| 041 ## - Language |
|---|
| Language code of text/sound track or separate title |
eng |
| 050 00 - LIBRARY OF CONGRESS CALL NUMBER |
|---|
| Classification number |
RS380 |
| Item number |
.K537 2010 |
| 082 00 - DEWEY DECIMAL CLASSIFICATION NUMBER |
|---|
| Classification number |
615.19 |
| Edition number |
22 |
| Item number |
K537 |
| 100 1# - MAIN ENTRY--PERSONAL NAME |
|---|
| Personal name |
Kisaalita, William Ssempa, |
| Dates associated with a name |
1953- |
| 9 (RLIN) |
4191 |
| 245 10 - IMMEDIATE SOURCE OF ACQUISITION NOTE |
|---|
| Title |
3D cell-based biosensors in drug discovery programs : |
| Remainder of title |
microtissue engineering for high throughput screening / |
| Statement of responsibility, etc |
William S. Kisaalita. |
| 246 3# - VARYING FORM OF TITLE |
|---|
| Title proper/short title |
Three-dimensional cell-based biosensors in drug discovery programs |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. (IMPRINT) |
|---|
| Place of publication, distribution, etc |
Boca Raton, FL : |
| Name of publisher, distributor, etc |
CRC Press, |
| Date of publication, distribution, etc |
2010. |
| 300 ## - PHYSICAL DESCRIPTION |
|---|
| Extent |
xvii, 386 p. : |
| Other physical details |
ill. ; |
| Dimensions |
25 cm. |
| 504 ## - BIBLIOGRAPHY, ETC. NOTE |
|---|
| Bibliography, etc |
Includes bibliographical references and indexes. |
| 505 0# - FORMATTED CONTENTS NOTE |
|---|
| Formatted contents note |
Biosensors and bioassays -- Target-driven drug discovery -- Comparative transcriptional profiling and proteomics -- Comparative structure and function -- Chemical microenvironmental factors -- Spatial and temporal microenvironmental factors -- Material physical property and force microenvironmental factors -- Proteomics as a promising tool in the search for 3D biomarkers -- Readout present and near future -- Ready-to-use commercial 3D plates -- Challenges to adopting 3D cultures in HTS programs -- Cases for 3D cultures in drug discovery -- Ideal case study design. |
| 520 ## - SUMMARY, ETC. |
|---|
| Summary, etc |
"This book is based upon cutting-edge research conducted in the authors lab (Cellular Bioengineering), which over the past decade has developed a number of sophisticated techniques to facilitate use of 3D cell based assays or biosensors. This book uses data from peer-reviewed publications to conclusively justify use of 3D cell cultures in cell-based biosensors (assays) for (HTS). The majority of assays performed in accelerated drug discovery processes are biochemical in nature, but there is a growing demand for live cell-based assays. Unlike biochemical ones, cellular assays are functional approximations of in vivo biological conditions and can provide more biologically relevant information"--Provided by publisher. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name as entry element |
Pharmaceutical biotechnology. |
| 9 (RLIN) |
4192 |
|
|---|
| Topical term or geographic name as entry element |
Biosensors. |
| 9 (RLIN) |
1721 |
|
|---|
| Topical term or geographic name as entry element |
High throughput screening (Drug development) |
| 9 (RLIN) |
4193 |
|
|---|
| Topical term or geographic name as entry element |
Biosensing Techniques |
| General subdivision |
methods. |
| 9 (RLIN) |
4194 |
|
|---|
| Topical term or geographic name as entry element |
Cells, Cultured. |
| 9 (RLIN) |
4195 |
|
|---|
| Topical term or geographic name as entry element |
Drug Discovery. |
| 9 (RLIN) |
4196 |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
|---|
| Source of classification or shelving scheme |
|
| Item type |
Book |
