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3D cell-based biosensors in drug discovery programs : microtissue engineering for high throughput screening /

by Kisaalita, William Ssempa,
Published by : CRC Press, (Boca Raton, FL :) Physical details: xvii, 386 p. : ill. ; 25 cm. ISBN: 1420073494 Subject(s): Pharmaceutical biotechnology. | Biosensors. | High throughput screening (Drug development) | Biosensing Techniques %methods. | Cells, Cultured. | Drug Discovery. Year: 2010
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Item type Location Call Number Status Notes Date Due
Book Book AUM Main Library 615.19 K537 (Browse Shelf) Available JBC/2011/11367
Book Book AUM Main Library 615.19 K537 (Browse Shelf) Available JBC/2011/11367

Includes bibliographical references and indexes.

Biosensors and bioassays -- Target-driven drug discovery -- Comparative transcriptional profiling and proteomics -- Comparative structure and function -- Chemical microenvironmental factors -- Spatial and temporal microenvironmental factors -- Material physical property and force microenvironmental factors -- Proteomics as a promising tool in the search for 3D biomarkers -- Readout present and near future -- Ready-to-use commercial 3D plates -- Challenges to adopting 3D cultures in HTS programs -- Cases for 3D cultures in drug discovery -- Ideal case study design.

"This book is based upon cutting-edge research conducted in the authors lab (Cellular Bioengineering), which over the past decade has developed a number of sophisticated techniques to facilitate use of 3D cell based assays or biosensors. This book uses data from peer-reviewed publications to conclusively justify use of 3D cell cultures in cell-based biosensors (assays) for (HTS). The majority of assays performed in accelerated drug discovery processes are biochemical in nature, but there is a growing demand for live cell-based assays. Unlike biochemical ones, cellular assays are functional approximations of in vivo biological conditions and can provide more biologically relevant information"--Provided by publisher.

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