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Item type | Location | Call Number | Status | Notes | Date Due |
---|---|---|---|---|---|
Book | AUM Main Library | 615.19 K537 (Browse Shelf) | Available | JBC/2011/11367 | |
Book | AUM Main Library | 615.19 K537 (Browse Shelf) | Available | JBC/2011/11367 |
Includes bibliographical references and indexes.
Biosensors and bioassays -- Target-driven drug discovery -- Comparative transcriptional profiling and proteomics -- Comparative structure and function -- Chemical microenvironmental factors -- Spatial and temporal microenvironmental factors -- Material physical property and force microenvironmental factors -- Proteomics as a promising tool in the search for 3D biomarkers -- Readout present and near future -- Ready-to-use commercial 3D plates -- Challenges to adopting 3D cultures in HTS programs -- Cases for 3D cultures in drug discovery -- Ideal case study design.
"This book is based upon cutting-edge research conducted in the authors lab (Cellular Bioengineering), which over the past decade has developed a number of sophisticated techniques to facilitate use of 3D cell based assays or biosensors. This book uses data from peer-reviewed publications to conclusively justify use of 3D cell cultures in cell-based biosensors (assays) for (HTS). The majority of assays performed in accelerated drug discovery processes are biochemical in nature, but there is a growing demand for live cell-based assays. Unlike biochemical ones, cellular assays are functional approximations of in vivo biological conditions and can provide more biologically relevant information"--Provided by publisher.
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