Structure-Activity Relationships (SAR) of Melanocortin and Agouti-Related (AGRP) Peptides -- Melanocortin Signalling Mechanisms -- Distribution and Function of Melanocortin Receptors within the Brain -- Drugs, Exercise, and the Melanocortin-4 Receptor— Different Means, Same Ends: Treating Obesity -- Melanocortins in Brain Inflammation: The Role of Melanocortin Receptor Subtypes -- Melanocortins and the Cholinergic Anti-Inflammatory Pathway -- Melanocortin Control of Cell Trafficking in Vascular Inflammation -- Terminal Signal: Anti-Inflammatory Effects of ?-Melanocyte-Stimulating Hormone Related Peptides Beyond the Pharmacophore -- Protective Effects of Melanocortins in Systemic Host Reactions -- Development of ?-Melanocortin Analogs for Melanoma Prevention and Targeting -- MSH Radiopeptides for Targeting Melanoma Metastases -- Applications of the Role of ?-MSH in Ocular Immune Privilege.

This book represents the joint effort of an international group of scientists who are at the forefront of research in the field. The volume spans information on chemistry, pharmacology, distribution, and therapeutic potential of melanocortins. A recurrent theme of this volume is the role played by distinct melanocortin receptors in mediating melanocortin effects. Although these receptors have been identified and well-characterized, information in the book indicates that definite categorization of their expression and function in different conditions still needs major work.