Previous edition: 2020

Includes index

Introduction to the Immune System : Nomenclature, General Properties, and Components. Infections and immunity ; Immunologic disorders ; Stages of host defense: Innate and adaptive immunity ; Properties of adaptive immune responses ; Cells of the adaptive immune system ; Tissues of the immune system ; Summary ; Review questions -- Innate Immunity : The Early Defense Against Infections. General features and specificity of innate immune responses ; Cellular receptors for microbes and damaged cells ; Components of innate immunity ; Innate immune reactions ; Role of innate immunity in stimulating adaptive immune responses ; Summary ; Review questions -- Antigen Presentation to T Lymphocytes and the Functions of Major Histocompatibility Complex Molecules : What T Lymphocytes See. Antigens recognized by T lymphocytes ; Capture of protein antigens by antigen-presenting cells ; Structure and function of major histocompatability complex molecules ; Processing and presentation of protein antigens ; Functions of antigen-presenting cells in addition to antigen display ; Antigen recognition by other T lymphocytes ; Summary ; Review questions -- Antigen Recognition in the Adaptive Immune System : Structure of Lymphocyte Antigen Receptors and Development of Immune Repertoires. Antigen receptors of lymphocytes ; Development of B and T lymphocytes ; Summary ; Review questions --

T Cell-Mediated Immunity : Activation of T Lymphocytes. Steps in T cell responses ; Antigen recognition and costimulation ; Biochemical pathways of T cell activation ; Functional responses of T lymphocytes to antigen and costimulation ; Regulation of T cell responses by inhibitory receptors (Coinhibitors) ; Migration of T lymphocytes in cell-mediated immune reactions ; Decline of the immune response ; Summary ; Review questions -- Effector Mechanisms of T Cell-Mediated Immunity : Functions of T Cells in Host Defense. Types of T cell-mediated immune reactions ; Development and functions of CD4⁺ effector T lymphocytes ; Differentiation and functions of CD8⁺ cytotoxic T lymphocytes ; Resistance of pathogenic microbes to cell-mediated immunity ; Summary ; Review questions -- Humoral Immune Responses : Activation of B Lymphocytes and Production of Antibodies. Phases and types of humoral immune responses ; Stimulation of B lymphocytes by antigen ; Functions of helper T lymphocytes in humoral immune responses ; Antibody responses to T-independent antigens ; Regulation of humoral immune responses ; Summary ; Review questions -- Effector Mechanisms of Humoral Immunity : Elimination of Extracellular Microbes and Toxins. Properties of antibodies that determine effector functions ; Neutralization of microbes and microbial toxins ; Opsonization and phagocytosis ; Antibody-dependent cellular cytotoxicity ; Immunoglobulin E- and mast cell-mediated reactions ; The complement system ; Functions of antibodies at special anatomic sites ; Evasion of humoral immunity by microbes ; Vaccination ; Summary ; Review questions --

Immunologic Tolerance and Autoimmunity : Self-Nonself Discrimination in the Immune System and Its Failure. Immunologic tolerance: General principles and significance ; Central T lymphocyte tolerance ; Peripheral T lymphocyte tolerance ; B lymphocyte tolerance ; Tolerance to commensal microbes and fetal antigens ; Autoimmunity ; Summary ; Review questions -- Tumor and Transplantation Immunology : Immune Responses to Cancer Cells and Normal Foreign Cells. Immune responses against tumors ; Immune responses against transplants ; Summary ; Review questions -- Hypersensitivity : Disorders Caused by Immune Responses. Types of hypersensitivity reactions ; Immediate hypersensitivity ; Diseases caused by antibodies specific for cell and tissue antigens ; Diseases caused by antigen-antibody complexes ; Diseases caused by T lymphocytes ; Summary ; Review questions -- Immunodeficiency Diseases : Disorders Caused by Defective Immunity. Primary (congenital) immunodeficiencies ; Acquired (secondary) immunodeficiencies ; Acquired Immunodeficiency Syndrome (AIDS) ; Summary ; Review questions -- Glossary -- Appendix I: Principal Features of Selected CD Molecules -- Appendix II: Cytokines -- Appendix III: Clinical Cases. Case 1: Lymphoma ; Case 2: Heart transplantation complicated by allograft rejection ; Case 3: Allergic asthma ; Case 4: Systemic lupus erythematosus ; Case 5: Human immunodeficiency virus infection: Acquired Immunodeficiency Syndrome ; Case 6: SARS CoV-2 infection: COVID-19 -- Answers to Review Questions

"The essential immunology information you need to know in a concise, authoritative, and easy-to-understand text! Meticulously reviewed and updated for today's medical students, 'Basic Immunology', 7th Edition, is a concise text expertly written by the same distinguished author team as the best-selling, comprehensive text, 'Cellular and Molecular Immunology'. This focused, easy-to-understand volume has been fully revised to include recent important advances in our understanding and knowledge of the immune system. A student favorite through six outstanding editions, this new edition uses full-color illustrations and clinical images, useful tables, and practical features such as Summary Point boxes, end-of-chapter Review Questions, glossary terms, and clinical cases -- all designed to help students master this complex topic in the most efficient, effective manner possible. Emphasizes clinical aspects of immunology, including disease pathogenesis, development of novel therapies based on basic science, and an appendix of clinical cases for real-world application. Contains new and expanded content on pandemics, COVID-19, and herd immunity; resistance and susceptibility to COVID-19; RNA vaccines and hybrid viral vaccines; tumor immunotherapy; innate immune responses to viruses; mechanisms of immunologic tolerance; and immunotherapy for cancer and autoimmune, allergic, and other inflammatory diseases."--