Tracing the Early Cell Divisions of Mouse Embryos by Single Cell RNA-Seq -- Successes and Failures of Elegant Algorithms in Computational Biology -- Modeling without Borders: Creating and Annotating VCell Models Using the Web -- Touring Protein Space with Matt -- Fixed-Parameter Algorithm for General Pedigrees with a Single Pair of Sites -- Analysis of Temporal-spatial Co-variation within Gene Expression Microarray Data in an Organogenesis Model -- Human Genome Annotation -- Extensions and Improvements to the Chordal Graph Approach to the Multi-state Perfect Phylogeny Problem -- Analysis of Gene Interactions Using Restricted Boolean Networks and Time-Series Data -- Residue Contexts: Non-sequential Protein Structure Alignment Using Structural and Biochemical Features -- Essential Proteins Discovery from Weighted Protein Interaction Networks -- Identifying Differentially Abundant Metabolic Pathways in Metagenomic Datasets -- A Novel Approach for Compressing Phylogenetic Trees -- Structure of Proximal and Distant Regulatory Elements in the Human Genome -- Combinatorics in Recombinational Population Genomics -- Uncovering Hidden Phylogenetic Consensus -- An Agglomerate Algorithm for Mining Overlapping and Hierarchical Functional Modules in Protein Interaction Networks -- Fast Protein Structure Alignment -- Predicting and Analyzing Cellular Networks -- A Consensus Tree Approach for Reconstructing Human Evolutionary History and Detecting Population Substructure -- Inferring Evolutionary Scenarios for Protein Domain Compositions -- Local Structural Alignment of RNA with Affine Gap Model -- Fast Computation of the Exact Hybridization Number of Two Phylogenetic Trees -- “Master-Slave” Biological Network Alignment -- Deciphering Transcription Factor Binding Patterns from Genome-Wide High Density ChIP-chip Tiling Array Data -- The Expected Fitness Cost of a Mutation Fixation under the One-Dimensional Fisher Model.

This volume constitutes the refereed proceedings of the 6th International Symposium on Bioinformatics Research and Applications, ISBRA 2010, held in Storrs, CT, USA, in May 2010. The 20 revised full papers and 6 invited talks presented were carefully reviewed and selected out of 57 submissions. Topics presented span all areas of bioinformatics and computational biology, including the development of experimental or commercial systems.