The two-volume set LNCS 6593 and 6594 constitutes the refereed proceedings of the 10th International Conference on Adaptive and Natural Computing Algorithms, ICANNGA 2010, held in Ljubljana, Slovenia, in April 2010. The 83 revised full papers presented were carefully reviewed and selected from a total of 144 submissions. The second volume includes 41 papers organized in topical sections on pattern recognition and learning, soft computing, systems theory, support vector machines, and bioinformatics.