This volume constitutes the refereed proceedings of the 10th International Symposium on Experimental Algorithms, SEA 2011, held in Kolimpari, Chania, Crete, Greece, in May 2011. The 36 revised full papers presented together with 2 invited papers were carefully reviewed and selected from 83 submissions and present current research in the area of design, analysis, and experimental evaluation and engineering of algorithms, as well as in various aspects of computational optimization and its applications.