This book constitutes the refereed proceedings of the 10th International Conference on Ad-hoc, Mobile, and Wireless Networks, ADHOC-NOW 2011 held in Paderborn, Germany, July 18-20, 2011. The 23 revised full papers presented together with 4 invited papers were carefully reviewed and selected from 53 submissions. The papers are organized in topical sections on routing and activity scheduling, topology control, medium access control, security, mobility management and handling, applications and evaluation, and analytical considerations.