The Adhesion GPCRs; Gene Repertoire, Phylogeny and Evolution -- 7TM-Cadherins: Developmental Roles and Future Challenges -- Latrophilin Signalling in Tissue Polarity and Morphogenesis -- GPS Proteolytic Cleavage of Adhesion-GPCRs -- The Latrophilins, “Split-Personality” Receptors -- Studies on the Very Large G Protein-Coupled Receptor: From Initial Discovery to Determining its Role in Sensorineural Deafness in Higher Animals -- Adhesion-GPCRs in the CNS -- GPR56 Interacts with Extracellular Matrix and Regulates Cancer Progression -- Adhesion-GPCRs in Tumorigenesis -- Immunity and Adhesion-GPCRs -- CD97 in Leukocyte Trafficking -- The Role of CD97 in Regulating Adaptive T-Cell Responses -- F4/80: The Macrophage-Specific Adhesion-GPCR and its Role in Immunoregulation -- Signal Transduction Mediated through Adhesion-GPCRs -- Emerging Roles of Brain-Specific Angiogenesis Inhibitor 1 -- Adhesion-GPCRs in the Male Reproductive Tract.

The field of adhesion‑GPCR biology has indeed become large enough to require a volume dedicated solely to this field. The contributors to this book have made a courageous effort to address the key concepts of adhesion‑GPCR biology, including the evolution and biochemistry of adhesion‑GPCRs; there are extensive discussions on the functional nature of these receptors during development, the immune response and tumourgenesis. Finally, there are chapters dedicated to adhesion‑GPCR signalling, an area of intense investigation. This volume focuses on the recent advances in adhesion‑GPCR biology.