Pharmacogenetics in Clinical and Forensic Toxicology: Overdoses and Deaths -- Drug Interactions with Benzodiazepines: Epidemiologic Correlates with Other CNS Depressants and In Vitro Correlates with Inhibitors and Inducers of Cytochrome P450 3A4 -- Antiepileptic Drugs -- Opioids and Opiates -- Tricyclic Antidepressant Drug Interactions -- Selective Serotonin Reuptake Inhibitors -- Antipsychotic Drugs and Interactions: Implications for Criminal and Civil Litigation -- Drugs of Abuse -- Cardiovascular Drugs -- Antimicrobial Drugs -- Nonsteroidal Anti-inflammatory Drugs, Disease-Modifying Antirheumatic Drugs, and Agents Used in Gout -- Food and Drug Interactions -- Pharmacokinetic and Pharmacodynamic Interactions Between Alcohol and Other Drugs -- Nicotine and Tobacco -- Anabolic Doping Agents -- Drug Interaction Litigation -- Psychotropic Medications and Crime: The Seasoning of the Prozac Defense.

Adverse drug reactions and interactions are still a major headache for healthcare professionals around the world. The US Food and Drug Administration's database recorded almost 300,000 serious adverse events in 2009 alone, of which 45,000 instances proved fatal. This updated new edition of the indispensable guide to drug interactions incorporates fresh research completed since the book's original publication by Humana Press in 2004. Additions include a new section on pharmacogenomics, a rapidly growing field that explores the genetic basis for the variability of responses to drugs. This new material reviews important polymorphisms in drug metabolizing enzymes and applies the findings to forensic interpretation, using case studies involving opiates as exemplars. Existing chapters from the first edition have in most cases been updated and reworked to reflect new data or incorporate better tables and diagrams, as well as to include recent drugs and formulations. Recent references have been inserted too. The handbook features extra material on illicit drug use, with a new chapter tackling the subject that covers cocaine, amphetamines and cannabis, among others. The section on the central nervous system also deals with a number of drugs that are abused illicitly, such as benzodiazepines, opiates flunitrazepam and GHB, while so-called 'social' drugs such as alcohol and nicotine are still discussed in the book's section on environmental and social pharmacology. Focusing as before on detailed explanation and incorporating both pharmacokinetic and pharmacodynamic drug interactions, this book will continue to be a lodestar for health and forensic professionals as well as students.