Assessing Function and Functional Outcome in Schizophrenia -- Antipsychotics and Metabolics in the Post-CATIE Era -- Pharmacological Strategies for Enhancing Cognition in Schizophrenia -- Treatment Implications of the Schizophrenia Prodrome -- Antipsychotic Drug Development -- Antipsychotic Dosing and Drug Delivery -- Functional Brain Imaging in Schizophrenia: Selected Results and Methods -- Neurochemical Imaging in Schizophrenia -- A Selective Review of Volumetric and Morphometric Imaging in Schizophrenia -- Neurophysiological Measures of Sensory Registration, Stimulus Discrimination, and Selection in Schizophrenia Patients -- Eye Tracking Dysfunction in Schizophrenia: Characterization and Pathophysiology -- Prepulse Inhibition of the Startle Reflex: A Window on the Brain in Schizophrenia -- Neurocognition in Schizophrenia -- Animal Models of Schizophrenia -- Models of Neurodevelopmental Abnormalities in Schizophrenia -- Prefrontal Cortical Circuits in Schizophrenia -- Thalamic Pathology in Schizophrenia -- Hippocampal Pathology in Schizophrenia -- Integrative Circuit Models and Their Implications for the Pathophysiologies and Treatments of the Schizophrenias -- Experimental Approaches for Identifying Schizophrenia Risk Genes -- Epigenetics of Schizophrenia -- Molecules, Signaling, and Schizophrenia.

Schizophrenia research is in a dynamic state; this text gives a foothold for where we stand today, and a map for where our field may move tomorrow. Chapters on treatment describe major changes in clinical and neural targets, and new technologies for drug delivery, even as we struggle to address adverse effects of old treatments. The text next reviews advances in the experimental analysis of the schizophrenias. Where we once faced a paucity of biological signals, our field now sees an expanding list of clear neural abnormalities, and chapters focus on those in circuitry connecting prefrontal cortex, thalamus and mesial temporal lobes. The rapid evolution of schizophrenia genetics is described: older strategies for finding disorder genes, jettisoned in favor of studies of aberrant copy number variants, rare mutations or DNA methylation, and of molecular signaling pathways that trigger downstream disturbances in critical brain circuits. With what we now know about the complex biology of the schizophrenias, a key question becomes whether we can manipulate this biology in a way that fundamentally changes the course of this disorder. This text provides a context for students, investigators and clinicians to understand this stage in our evolving field, and to look ahead to the future of schizophrenia research.