Cell Adhesions and Signaling: A Tool for Biocompatibility Assessment -- Development of Provisional Extracellular Matrix on Biomaterials Interface: Lessons from In Vitro Cell Culture -- Endothelial Progenitor Cells for Tissue Engineering and Tissue Regeneration -- Dermal Precursors and the Origins of the Wound Fibroblast -- Cell Based Therapies: What Do We Learn from Periosteal Osteochondrogenesis? -- Bioreactor Systems in Regenerative Medicine -- Biomimetic Approaches to Design of Tissue Engineering Bioreactors -- The Nature of the Thermal Transition Influences the Shape-Memory Behavior of Polymer Networks -- Nanoengineered Systems for Regenerative Medicine Surface Engineered Polymeric Biomaterials with Improved Bio-Contact Properties -- Nanocomposites for Regenerative Medicine -- Role of Spatial Distribution of Matricellular Cues in Controlling Cell Functions -- Materials Surface Effects on Biological Interactions -- Chemical and Physical Modifications of Biomaterial Surfaces to Control Adhesion of Cells -- Results of Biocompatibility Testing of Novel, Multifunctional Polymeric Implant Materials In-Vitro and In-Vivo -- UFOs, Worms, and Surfboards: What Shapes Teach Us About Cell–Material Interactions -- Nano-engineered Thin Films for Cell and Tissue-Contacting Applications -- Injectable Hydrogels: From Basics to Nanotechnological Features and Potential Advances -- Polyelectrolyte Complexes as Smart Nanoengineered Systems for Biotechnology and Gene Delivery.

The contributions to this book, all written by leading experts in their respective disciplines, describe and explore the various facets of regenerative medicine and highlight the role of the "the nano length scale" and of "nano-scale systems" in defining and controlling cell and tissue environments. The development of novel tissue-regeneration strategies requires the integration of new insights emerging from studies of cell-matrix interactions, cellular signalling processes, and developmental and systems biology, into biomaterials design, ideally via a systems approach. The chapters cover a wide spectrum of topics ranging from stem cell biology, developmental biology, cell-matrix interactions, and matrix biology to surface science, materials processing and drug delivery. The book will be an especially valuable resource for researchers developing regenerative medicine paradigms that combine these facets into clinically translatable solutions.