Metal-Catalyzed Cross-Coupling Reactions -- A Historical Overview of Metal-Catalyzed Cross-Coupling Reactions -- Mechanism and Fundamental Reactions -- Applications of Cross-Coupling Reactions -- Natural Product Synthesis -- Pharmaceuticals -- Liquid Crystals -- Conjugated Polymers -- Recent Advances in Cross-Coupling Reactions -- With Aryl Chlorides, Tosylates, and Methylates -- With Alkyl Electrophiles.

“Applied Cross-Coupling Reactions” provides students and teachers of advanced organic chemistry with an overview of the history, mechanisms and applications of cross-coupling reactions. Since the discovery of the transition-metal-catalyzed cross-coupling reactions in 1972, numerous synthetic uses and industrial applications have been developed. The mechanistic studies of the cross-coupling reactions have disclosed that three fundamental reactions: oxidative addition, transmetalation, and reductive elimination, are involved in a catalytic cycle. Cross-coupling reactions have allowed us to produce a variety of compounds in industrial areas, such as natural products, pharmaceuticals, liquid crystals and conjugate polymers for use in electronic devices. Indeed, the Nobel Prize for Chemistry 2010 was awarded for work on cross-coupling reactions In this book, the recent trends of cross-coupling reactions are also introduced from the viewpoint of designing the synthesis, and catalytic activities of the transition-metal catalysts.