Chemoprevention, Staging, and Novel Therapeutic Targets -- Chemoprevention of Ovarian Cancer -- Staging and Surgical Treatment -- Novel Therapeutic Targets -- Biomarker Targets and Novel Therapeutics -- Tumorigenesis and Biomarkers -- Tumor Suppressor Genes -- Epigenetics and Ovarian Cancer -- Aberrant Epithelial Differentiation in Ovarian Cancer -- The Human Kallikrein Gene Family: New Biomarkers for Ovarian Cancer -- Soluble Epidermal Growth Factor Receptor: A Biomarker of Epithelial Ovarian Cancer -- Activated Epidermal Growth Factor Receptor in Ovarian Cancer -- Tumor Progression, Metastasis, Research Models -- Ras-Superfamily GTP-ases in Ovarian Cancer -- Lipid Generation and Signaling in Ovarian Cancer -- Lysophosphatidic Acid and Invasion -- Cell Adhesion in Ovarian Cancer -- Microenvironmental Regulation of Ovarian Cancer Metastasis -- Organotypic Models of Metastasis: A Three-dimensional Culture Mimicking the Human Peritoneum and Omentum for the Study of the Early Steps of Ovarian Cancer Metastasis -- Animal Models of Ovarian Cancer.

Ovarian carcinoma continues to be responsible for more deaths than all other gynecologic malignancies combined, due to a continued inability to achieve detection of early (rather than advanced) stage disease and the lack of effective tumor-specific therapeutics. Ovarian carcinogenesis, invasion, and metastatic dissemination require a complex cascade of interrelated genetic, molecular, and biochemical events that regulate the neoplastic transition of normal ovarian surface epithelium. This second edition includes exciting new advances in ovarian cancer detection and treatment and provides an analysis of current research into aspects of malignant transformation, growth control, and metastasis. A more detailed understanding of these processes may ultimately translate into the development of novel approaches for the detection and control of ovarian cancer. "Ovarian Cancer prevention, detection and treatment remain a significant health care challenge. In this text thought leaders in the field address the critical biologic and clinical issues relevant to the disease. A comprehensive spectrum of topics is covered providing up to date information on scientific discoveries and management considerations." Steven T. Rosen, M.D.