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Item type | Location | Call Number | Status | Date Due |
---|---|---|---|---|
E-Book | AUM Main Library | 572.84 (Browse Shelf) | Not for loan |
572.838 E93Evolution after gene duplication / | 572.838 R56Integrated molecular evolution / | 572.838 R56Integrated molecular evolution / | 572.84Targeting Functional Centers of the Ribosome | 572.84RNA 3D Structure Analysis and Prediction | 572.84RNA Metabolism in Trypanosomes |
Introduction -- Methods -- Results -- Discussion.
This thesis describes research into the mode of function, inhibition, and evolution of the ribosomal catalytic center, the Peptidyl Transferase Center (PTC)--research that has already led to attempts at improving PTC antibiotics. The PhD candidate carried out two parallel studies. One using a combination of X-ray crystallography, biochemistry, molecular biology, and theoretical studies to obtain crystal structures of ribosomal particles with antibiotics that target the PTC, revealing the modes of action, resistance, cross-resistance and discrimination between ribosomes of eubacterial pathogens and eukaryotic hosts. In the second parallel study, the candidate synthesized a ribosomal substructure--one that may represent the minimal entity capable of catalyzing peptide bond formation--shedding light on the origin of the ribosome itself.
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