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Evaluation of drug candidates for preclinical development : pharmacokinetics, metabolism, pharmaceutics, and toxicology /

Authors: Han, Chao. | Davis, Charles B.%(Charles Baldwin) | %Wang, Binghe,%PhD. Series: Wiley series in drug discovery and development Published by : John Wiley & Sons, (Hoboken, N.J. :) Physical details: x, 289 p., [2] p. of plates : ill. (some col.) ; 25 cm. ISBN: 0470044918 Subject(s): Drug development. | Pharmacokinetics. | Drugs %Metabolism. | Drug Evaluation, Preclinical. | Drug Discovery. | Drug Industry %standards. | Pharmaceutical Preparations %metabolism. | Pharmacology %methods. Year: 2010
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Includes bibliographical references and index.

Pharmacokinetics in preclinical drug development : an overview / Dion Brocks -- The role of membrane transporters in drug disposition / Fanfan Zhou, Peng Duan, and Guofeng You -- Cytochrome P450 : structure, function, and application in drug discovery and development / Ramesh B. Bambal and Stephen E. Clarke -- The role of drug metabolism and metabolite identification in drug discovery / Xiangming Guan -- Protein binding in drug discovery and development / Vikram Ramanathan and Nimish Vachharajani -- Prediction of the pharmacokinetics in humans / Chao Han and Ramesh Bambal -- Pharmaceutics developability assessment / Lian Huang, Jinquan Dong, and Shyam Karki -- Safety assessment in drug discovery / Vito G. Sasseville, William R. Foster, and Bruce D. Car -- Assessment of strategies utilized to minimize the potential for induction of acquired long QT syndrome and torsade de pointes / Khuram W. Chaudhary and Barry S. Brown.

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